Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018

The applications of whole exome sequencing (WES) technologies have witnessed growth in recent years, which can be primarily attributed to the availability of advanced systems as well as the low cost of conducting exome sequencing, as compared with that of whole genome sequencing. The technological advancement is evident from the number of improved versions of existing sequencers released in recent years. For instance, in January 2014, the leading player in the whole exome sequencing market, Illumina, Inc. (U.S.), launched its NextSeq 500 System, which combines high-throughput performance with an affordable desktop form factor. This system is expected to enable researchers to perform sequencing in less than a day.

The major factors driving the growth of this market include its low cost and high speed, increase in applications areas for exome sequencing technologies, global alliances amongst leading research institutes to boost drug discovery, and the entry of new players in the whole-exome sequencing market. However, the high cost of instruments, the need for skilled professionals and high reliability on grants are hindering the market’s growth.

The services segment has the largest share of the global whole exome sequencing market, since it has a variety of applications in all areas, including diagnostics, drug discovery and development, personalized medicine, and agriculture and animal research. Diagnostics emerged as the largest whole exome sequencing application, primarily because of an increase in the usage of exome sequencing technologies in cancer and rare disease research.

In the years to come, the whole exome sequencing market is expected to experience high growth in Asia, particularly in China and India. These countries will serve as new revenue pockets for whole exome sequencing products and services companies. High growth in these regions can be attributed to growth in the pharmaceutical and biotech industry and crop research, increased funding scenarios and collaborations with established market players. U.S. and Europe are witnessing steady growth owing to new applications in diagnostics, applied markets, and technological advancements in these regions. Rest of the world (RoW) includes regions such as Latin America, Africa, the Middle East, and Pacific countries, which have increased focus on research and gaining funds, thus increasing the potential for whole exome sequencing in these regions.

While the global whole exome sequencing products market witnesses low competitive intensity, competition is strong in the services market, with few big firms and many small companies in the fray offering similar services. These companies adopt various strategies (innovations, acquisitions, and geographic expansions) to increase their market shares and establish a strong foothold in the global market.

Reasons to Buy the Report:

The report will enrich both established firms as well as new entrants/smaller firms to gauge the pulse of the market, which in turn will help firms garner a greater market share. Firms purchasing the report could use any one or a combination of the below mentioned five strategies (market penetration, product development/innovation, market development, market diversification, and competitive assessment) for strengthening their market shares.

The report provides insights on the following pointers:

‧ Market Penetration: Comprehensive information on the product portfolios of and services offered by top players in the whole exome sequencing market. The report analyzes the whole exome sequencing market by products and services

‧ Product Development/Innovation: Detailed insights on upcoming technologies, research and development activities, and new product launches in the whole exome sequencing market

‧ Market Development: Comprehensive information about the lucrative emerging markets. The report analyzes markets for various whole exome sequencing technologies and services across geographies

‧ Market Diversification: Exhaustive information about new products and services, untapped geographies, recent developments, and investments in the whole exome sequencing market

‧ Competitive Assessment: In-depth assessment of market shares, strategies, products and services, distribution networks, and manufacturing capabilities of leading players in the whole exome sequencing market

TABLE OF CONTENTS

1 INTRODUCTION 22
1.1 OBJECTIVES OF THE STUDY 22
1.2 MARKETS COVERED 23
1.3 STAKEHOLDERS 24
1.4 RESEARCH METHODOLOGY 25
1.4.1 SECONDARY RESEARCH 25
1.4.2 PRIMARY RESEARCH 27
1.4.2.1 Key data points from primary sources 28
1.4.3 MARKET SIZE ESTIMATION METHODOLOGY 29
1.4.4 MARKET FORECAST MODEL 32
1.4.5 MARKET DATA VALIDATION AND DATA TRIANGULATION 33
1.5 ASSUMPTIONS 35
2 EXECUTIVE SUMMARY 36
3 MARKET OVERVIEW 41
3.1 INTRODUCTION 42
3.2 MARKET DYNAMICS 42
3.2.1 DRIVERS 43
3.2.1.1 Low cost and high speed of the WES technology to drive the growth of the market 43
3.2.1.2 Increasing number of new scientific applications to fuel the market growth 44
3.2.1.3 Adoption of WES technology by new consumers to propel the market growth 45
3.2.1.4 Global alliances amongst leading research institutes to trigger drug discovery 45
3.2.1.5 Entry of new players is propelling the growth of the WES market 46

3.2.2 RESTRAINTS 47
3.2.2.1 Need for skilled professionals 47
3.2.2.2 High reliability on grants to restrict growth 47
3.2.2.3 Ethical and legal issues related to whole exome sequencing 47
3.2.3 OPPORTUNITY 48
3.2.3.1 Personalized medicine to fuel the demand for WES technology 48
3.3 MARKET SHARE ANALYSIS 49
3.3.1 WHOLE EXOME SEQUENCING PRODUCTS MARKET, BY KEY PLAYER 49
3.3.2 WHOLE EXOME SEQUENCING SERVICES MARKET,
BY KEY PLAYER 53
4 WHOLE EXOME SEQUENCING MARKET, BY PRODUCTS AND SERVICES 59
4.1 INTRODUCTION 60
4.2 SYSTEMS 64
4.2.1 INTRODUCTION 64
4.2.2 HISEQ SERIES 66
4.2.2.1 HiSeq 2500 and HiSeq 1500 66
4.2.3 MISEQ 66
4.2.4 ION TORRENT PLATFORMS 67
4.2.4.1 Ion PGM and Ion Proton 67
4.3 KITS 68
4.3.1 INTRODUCTION 68
4.3.2 DNA FRAGMENTATION, END REPAIR, A-TAILING, AND SIZE SELECTION KITS 71
4.3.3 LIBRARY PREPARATION KITS 73
4.3.4 TARGET ENRICHMENT KITS 75
4.4 SERVICES 77
4.4.1 INTRODUCTION 77
4.4.2 SEQUENCING SERVICES MARKET 78
4.4.3 DATA ANALYSIS (BIOINFORMATICS) SERVICES 80
4.4.4 OTHER SERVICES 81
5 GLOBAL WHOLE EXOME SEQUENCING MARKET,
BY TECHNOLOGY 83
5.1 INTRODUCTION 84
5.2 SEQUENCING BY SYNTHESIS (SBS) 86
5.2.1 TECHNOLOGY 86
5.2.2 ADVANTAGES 86
5.2.3 LIMITATIONS 86
5.2.4 APPLICATIONS 87
5.2.5 PLATFORMS 87
5.3 ION SEMICONDUCTOR SEQUENCING 88
5.3.1 TECHNOLOGY 88
5.3.2 ADVANTAGES 88
5.3.3 LIMITATIONS 88
5.3.4 APPLICATIONS 88
5.3.5 PLATFORMS 89
5.4 OTHER TECHNOLOGIES 90
5.4.1 SEQUENCING BY LIGATION (SBL) 90
5.4.1.1 Technology 90
5.4.1.2 Advantages 90
5.4.1.3 Limitations 90
5.4.1.4 Applications 90
5.4.2 PYROSEQUENCING 91
5.4.2.1 Technology 91
5.4.2.2 Advantages 91
5.4.2.3 Applications 91
6 WHOLE EXOME SEQUENCING MARKET, BY APPLICATION 93
6.1 INTRODUCTION 94
6.2 DIAGNOSTICS 96
6.2.1 CANCER DIAGNOSTICS 99
6.2.2 MONOGENIC (MENDELIAN) DISORDERS 100
6.2.3 MONOGENIC TYPES OF DIABETES 102
6.2.4 OTHER DIAGNOSTIC APPLICATIONS 103
6.2.4.1 Common diseases and complex disorders 103
6.2.4.2 Movement disorders 103
6.2.4.3 HIV 103
6.3 DRUG DISCOVERY AND DEVELOPMENT 105
6.4 PERSONALIZED MEDICINE 107
6.5 AGRICULTURE & ANIMAL RESEARCH 109
6.6 OTHER APPLICATIONS 111
7 GLOBAL WHOLE EXOME SEQUENCING MARKET, BY END USER 112
7.1 INTRODUCTION 113
7.1.1 RESEARCH CENTERS AND ACADEMIC & GOVERNMENT INSTITUTES 115
7.1.2 HOSPITALS AND CLINICS 117
7.1.3 PHARMACEUTICAL & BIOTECHNOLOGY COMPANIES 118
7.1.4 OTHER END USERS 120
8 GLOBAL WHOLE EXOME SEQUENCING MARKET, BY GEOGRAPHY 121
8.1 INTRODUCTION 122
8.2 NORTH AMERICA 124
8.2.1 INCREASING USE OF WHOLE EXOME SEQUENCING FOR DIAGNOSIS OF RARE DISEASES PROPELS THE MARKET GROWTH 124
8.2.2 GOVERNMENT FUNDS FOR EXOME SEQUENCING TO BOOST THE MARKET 125
8.2.3 FAVORABLE INITIATIVES BY THE CANADIAN GOVERNMENT TO TRIGGER THE WES MARKET IN THE COUNTRY 125
8.2.4 CONFERENCES & ANNUAL MEETINGS TO CREATE AWARENESS ABOUT WES TECHNOLOGIES 126
8.3 EUROPE 137
8.3.1 INVESTMENTS IN RARE DISEASE RESEARCH LIKELY TO BOOST THE WES MARKET IN EUROPE 137
8.3.2 BELGIUM TO CONTRIBUTE SUBSTANTIALLY TO MARKET GROWTH IN EUROPE 138
8.3.3 INCREASING FUNDING FOR MOLECULAR DIAGNOSTICS IN EUROPE IS LIKELY TO PROPEL THE GROWTH OF THE WES MARKET 138
8.3.4 CONFERENCES & MEETINGS HOSTED IN EUROPE TO FUEL THE MARKET GROWTH 139
8.4 ASIA 150
8.4.1 ASIAN COUNTRIES ARE INCREASINGLY FOCUSING ON RESEARCH IN WES 150
8.4.2 STRATEGIC EXPANSIONS AND AQUISITIONS BY KEY PLAYERS IN CHINA TO BOOST THE MARKET 151
8.4.3 REGULAR FUNDING FROM INDIAN GOVERNMENT, AN IMPETUS TO THE WES MARKET 151
8.4.4 LARGE NUMBER OF CONFERENCES AND SYMPOSIA IN ASIA TO DRIVE MARKET GROWTH 152
8.5 REST OF THE WORLD (ROW) 161
8.5.1 BIOINFORMATICS AND BIOTECHNOLOGY RESEARCH IN LATIN AMERICA TO PROPEL THE GROWTH OF THE MARKET 162
8.5.2 GENOMIC & PROTEOMIC RESEARCH IN AUSTRALIA TO DRIVE THE GROWTH OF THE MARKET 162
8.5.3 FLOURISHING BIOTECHNOLOGY & PHARMACEUTICAL MARKETS IN BRAZIL TO BOLSTER THE GROWTH OF THE MARKET 163
9 COMPETITIVE LANDSCAPE 171
9.1 INTRODUCTION 171
9.2 AGREEMENTS, PARTNERSHIPS, & COLLABORATIONS 173
9.3 NEW PRODUCT LAUNCHES 176
9.4 EXPANSIONS 180
9.5 ACQUISITIONS 183
9.6 OTHERS 186
10 COMPANY PROFILES 189
10.1 ILLUMINA, INC. 189
10.2 THERMO FISHER SCIENTIFIC, INC. 196
10.3 BEIJING GENOMICS INSTITUTE (BGI) 204
10.4 MACROGEN, INC. 213
10.5 EUROFINS GENOMICS, INC. 217
10.6 AGILENT TECHNOLOGIES, INC. 222
10.7 AMBRY GENETICS 229
10.8 GENEWIZ, INC. 231
10.9 KNOME, INC. 234
10.10 ROCHE NIMBLEGEN, INC. 238
10.11 SENGENICS 243

*Details on Business Overview, Financial Overview, Services, Growth Strategy, & Recent Developments might not be captured in case of unlisted companies.